SMAD9-CCNA1 Fusion FISH Probe
The SMAD9-CCNA1 Fusion FISH Probe is used to confirm a fusion of the SMAD9 and CCNA1 genes. The fusion of the SMAD9 and CCNA1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMAD9-CCNA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-RERE | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-REOR | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-REGO | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-REGR | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-REAQ | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-ORRE | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-OROR | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-ORGO | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-GORE | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-GOOR | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-GOGO | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-GOGR | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-GRRE | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-GROR | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-GRGO | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-GRGR | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-AQRE | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-AQOR | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-AQGO | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-AQGR | 20 (40 μL) | 200 μL |
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| SMAD9-CCNA1-20-AQAQ | 20 (40 μL) | 200 μL |
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SMAD9 Gene Summary
The protein encoded by this gene is a member of the SMAD family, which transduces signals from TGF-beta family members. The encoded protein is activated by bone morphogenetic proteins and interacts with SMAD4. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2010]
Gene Name: SMAD Family Member 9
Chromosome: CHR13: 37418967 -37494409
Locus: 13q13.3
CCNA1 Gene Summary
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Cyclin A1
Chromosome: CHR13: 37005966 -37017019
Locus: 13q13.3
Gene Diseases
The SMAD9 CCNA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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