SMAD7-DYM Fusion FISH Probe
The SMAD7-DYM Fusion FISH Probe is used to confirm a fusion of the SMAD7 and DYM genes. The fusion of the SMAD7 and DYM genes has been associated with Liver Hepatocellular Carcinoma, and Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMAD7-DYM-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-RERE | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-REOR | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-REGO | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-REGR | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-REAQ | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-ORRE | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-OROR | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-ORGO | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-GORE | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-GOOR | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-GOGO | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-GOGR | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-GRRE | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-GROR | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-GRGO | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-GRGR | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-AQRE | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-AQOR | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-AQGO | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-AQGR | 20 (40 μL) | 200 μL |
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| SMAD7-DYM-20-AQAQ | 20 (40 μL) | 200 μL |
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SMAD7 Gene Summary
The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Name: SMAD Family Member 7
Chromosome: CHR18: 46446222 -46477081
Locus: 18q21.1
DYM Gene Summary
This gene encodes a protein which regulates Golgi-associated secretory pathways that are essential to endochondral bone formation during early development. This gene is also believed to play a role in early brain development. This gene is widely expressed in embryos and is particularly abundant in chodrocytes and brain tissues. It encodes a peripheral membrane protein which shuttles between the cytosol and Golgi complex. Mutations in this gene are associated with two types of recessive osteochondrodysplasia: Dyggve-Melchior-Clausen (DMC) dysplasia and Smith-McCort (SMC) dysplasia. [provided by RefSeq, Jun 2017]
Gene Name: Dymeclin
Chromosome: CHR18: 46570171 -46987079
Locus: 18q21.1
Gene Diseases
The SMAD7 DYM Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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