SMAD4-SKAP1 Fusion FISH Probe
The SMAD4-SKAP1 Fusion FISH Probe is used to confirm a fusion of the SMAD4 and SKAP1 genes. The fusion of the SMAD4 and SKAP1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMAD4-SKAP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-RERE | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-REOR | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-REGO | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-REGR | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-REAQ | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-ORRE | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-OROR | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-ORGO | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-GORE | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-GOOR | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-GOGO | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-GOGR | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-GRRE | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-GROR | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-GRGO | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-GRGR | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-AQRE | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-AQOR | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-AQGO | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-AQGR | 20 (40 μL) | 200 μL |
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| SMAD4-SKAP1-20-AQAQ | 20 (40 μL) | 200 μL |
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SMAD4 Gene Summary
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Aug 2017]
Gene Name: SMAD Family Member 4
Chromosome: CHR18: 48556582 -48611411
Locus: 18q21.2
SKAP1 Gene Summary
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]
Gene Name: Src Kinase Associated Phosphoprotein 1
Chromosome: CHR17: 46210801 -46507594
Locus: 17q21.32
Gene Diseases
The SMAD4 SKAP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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