SMAD4-NRG1 Fusion FISH Probe
The SMAD4-NRG1 Fusion FISH Probe is used to confirm a fusion of the SMAD4 and NRG1 genes. The fusion of the SMAD4 and NRG1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMAD4-NRG1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-RERE | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-REOR | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-REGO | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-REGR | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-REAQ | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-ORRE | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-OROR | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-ORGO | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-GORE | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-GOOR | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-GOGO | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-GOGR | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-GRRE | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-GROR | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-GRGO | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-GRGR | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-AQRE | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-AQOR | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-AQGO | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-AQGR | 20 (40 μL) | 200 μL |
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| SMAD4-NRG1-20-AQAQ | 20 (40 μL) | 200 μL |
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NRG1 Gene Summary
The protein encoded by this gene is a membrane glycoprotein that mediates cell-cell signaling and plays a critical role in the growth and development of multiple organ systems. An extraordinary variety of different isoforms are produced from this gene through alternative promoter usage and splicing. These isoforms are expressed in a tissue-specific manner and differ significantly in their structure, and are classified as types I, II, III, IV, V and VI. Dysregulation of this gene has been linked to diseases such as cancer, schizophrenia, and bipolar disorder (BPD). [provided by RefSeq, Apr 2016]
Gene Name: Neuregulin 1
Chromosome: CHR8: 31497267 -32600770
Locus: 8p12
SMAD4 Gene Summary
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to transforming growth factor (TGF)-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The protein acts as a tumor suppressor and inhibits epithelial cell proliferation. It may also have an inhibitory effect on tumors by reducing angiogenesis and increasng blood vessel hyperpermeability. The encoded protein is a crucial component of the bone morphogenetic protein signaling pathway. The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. [provided by RefSeq, Aug 2017]
Gene Name: SMAD Family Member 4
Chromosome: CHR18: 48556582 -48611411
Locus: 18q21.2
Gene Diseases
The SMAD4 NRG1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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