SMAD3-AAGAB Fusion FISH Probe
The SMAD3-AAGAB Fusion FISH Probe is used to confirm a fusion of the SMAD3 and AAGAB genes. The fusion of the SMAD3 and AAGAB genes has been associated with Bladder Urothelial Carcinoma, Sarcoma, and Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMAD3-AAGAB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-RERE | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-REOR | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-REGO | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-REGR | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-REAQ | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-ORRE | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-OROR | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-ORGO | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-GORE | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-GOOR | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-GOGO | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-GOGR | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-GRRE | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-GROR | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-GRGO | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-GRGR | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-AQRE | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-AQOR | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-AQGO | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-AQGR | 20 (40 μL) | 200 μL |
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| SMAD3-AAGAB-20-AQAQ | 20 (40 μL) | 200 μL |
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SMAD3 Gene Summary
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]
Gene Name: SMAD Family Member 3
Chromosome: CHR15: 67358194 -67487533
Locus: 15q22.33
AAGAB Gene Summary
The protein encoded by this gene interacts with the gamma-adaptin and alpha-adaptin subunits of complexes involved in clathrin-coated vesicle trafficking. Mutations in this gene are associated with type I punctate palmoplantar keratoderma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Name: Alpha And Gamma Adaptin Binding Protein
Chromosome: CHR15: 67493366 -67547074
Locus: 15q23
Gene Diseases
The SMAD3 AAGAB Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
| Sarcoma |
| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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