SMAD2-CD226 Fusion FISH Probe
The SMAD2-CD226 Fusion FISH Probe is used to confirm a fusion of the SMAD2 and CD226 genes. The fusion of the SMAD2 and CD226 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SMAD2-CD226-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-RERE | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-REOR | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-REGO | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-REGR | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-REAQ | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-ORRE | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-OROR | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-ORGO | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-ORAQ | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-GORE | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-GOOR | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-GOGO | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-GOGR | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-GOAQ | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-GRRE | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-GROR | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-GRGO | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-GRGR | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-GRAQ | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-AQRE | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-AQOR | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-AQGO | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-AQGR | 20 (40 μL) | 200 μL |
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| SMAD2-CD226-20-AQAQ | 20 (40 μL) | 200 μL |
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SMAD2 Gene Summary
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Gene Name: SMAD Family Member 2
Chromosome: CHR18: 45359465 -45457515
Locus: 18q21.1
CD226 Gene Summary
This gene encodes a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Gene Name: CD226 Molecule
Chromosome: CHR18: 67530192 -67624232
Locus: 18q22.2
Gene Diseases
The SMAD2 CD226 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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