SLPI-DDX27 Fusion FISH Probe
The SLPI-DDX27 Fusion FISH Probe is used to confirm a fusion of the SLPI and DDX27 genes. The fusion of the SLPI and DDX27 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SLPI-DDX27-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-RERE | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-REOR | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-REGO | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-REGR | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-REAQ | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-ORRE | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-OROR | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-ORGO | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-ORAQ | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-GORE | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-GOOR | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-GOGO | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-GOGR | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-GOAQ | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-GRRE | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-GROR | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-GRGO | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-GRGR | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-GRAQ | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-AQRE | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-AQOR | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-AQGO | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-AQGR | 20 (40 μL) | 200 μL |
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| SLPI-DDX27-20-AQAQ | 20 (40 μL) | 200 μL |
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SLPI Gene Summary
This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]
Gene Name: Secretory Leukocyte Peptidase Inhibitor
Chromosome: CHR20: 43880878 -43883206
Locus: 20q13.12
DDX27 Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017]
Gene Name: DEAD-box Helicase 27
Chromosome: CHR20: 47835831 -47860614
Locus: 20q13.13
Gene Diseases
The SLPI DDX27 Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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