SLIT3-ITPR2 Fusion FISH Probe
The SLIT3-ITPR2 Fusion FISH Probe is used to confirm a fusion of the SLIT3 and ITPR2 genes. The fusion of the SLIT3 and ITPR2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SLIT3-ITPR2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-RERE | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-REOR | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-REGO | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-REGR | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-REAQ | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-ORRE | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-OROR | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-ORGO | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-GORE | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-GOOR | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-GOGO | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-GOGR | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-GRRE | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-GROR | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-GRGO | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-GRGR | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-AQRE | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-AQOR | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-AQGO | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-AQGR | 20 (40 μL) | 200 μL |
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| SLIT3-ITPR2-20-AQAQ | 20 (40 μL) | 200 μL |
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ITPR2 Gene Summary
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
Gene Name: Inositol 1,4,5-trisphosphate Receptor Type 2
Chromosome: CHR12: 26488284 -26986131
Locus: 12p11.23
SLIT3 Gene Summary
The protein encoded by this gene is secreted, likely interacting with roundabout homolog receptors to effect cell migration. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Gene Name: Slit Guidance Ligand 3
Chromosome: CHR5: 168093070 -168728133
Locus: 5q34-q35.1
Gene Diseases
The SLIT3 ITPR2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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