SLC9A8-RAE1 Fusion FISH Probe
The SLC9A8-RAE1 Fusion FISH Probe is used to confirm a fusion of the SLC9A8 and RAE1 genes. The fusion of the SLC9A8 and RAE1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SLC9A8-RAE1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-RERE | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-REOR | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-REGO | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-REGR | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-REAQ | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-ORRE | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-OROR | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-ORGO | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-GORE | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-GOOR | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-GOGO | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-GOGR | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-GRRE | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-GROR | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-GRGO | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-GRGR | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-AQRE | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-AQOR | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-AQGO | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-AQGR | 20 (40 μL) | 200 μL |
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| SLC9A8-RAE1-20-AQAQ | 20 (40 μL) | 200 μL |
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RAE1 Gene Summary
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Ribonucleic Acid Export 1
Chromosome: CHR20: 55926144 -55953519
Locus: 20q13.31
SLC9A8 Gene Summary
Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral NaCl absorption in epithelia (Xu et al., 2008 [PubMed 18209477]).[supplied by OMIM, Apr 2009]
Gene Name: Solute Carrier Family 9 Member A8
Chromosome: CHR20: 48429249 -48508772
Locus: 20q13.13
Gene Diseases
The SLC9A8 RAE1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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