SLC3A2-NXF1 Fusion FISH Probe
The SLC3A2-NXF1 Fusion FISH Probe is used to confirm a fusion of the SLC3A2 and NXF1 genes. The fusion of the SLC3A2 and NXF1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SLC3A2-NXF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-RERE | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-REOR | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-REGO | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-REGR | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-REAQ | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-ORRE | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-OROR | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-ORGO | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-GORE | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-GOOR | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-GOGO | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-GOGR | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-GRRE | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-GROR | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-GRGO | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-GRGR | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-AQRE | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-AQOR | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-AQGO | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-AQGR | 20 (40 μL) | 200 μL |
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| SLC3A2-NXF1-20-AQAQ | 20 (40 μL) | 200 μL |
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SLC3A2 Gene Summary
This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]
Gene Name: Solute Carrier Family 3 Member 2
Chromosome: CHR11: 62623483 -62656355
Locus: 11q12.3
NXF1 Gene Summary
This gene is one member of a family of nuclear RNA export factor genes. Common domain features of this family are a noncanonical RNP-type RNA-binding domain (RBD), 4 leucine-rich repeats (LRRs), a nuclear transport factor 2 (NTF2)-like domain that allows heterodimerization with NTF2-related export protein-1 (NXT1), and a ubiquitin-associated domain that mediates interactions with nucleoporins. The LRRs and NTF2-like domains are required for export activity. Alternative splicing seems to be a common mechanism in this gene family. The encoded protein of this gene shuttles between the nucleus and the cytoplasm and binds in vivo to poly(A)+ RNA. It is the vertebrate homologue of the yeast protein Mex67p. The encoded protein overcomes the mRNA export block caused by the presence of saturating amounts of CTE (constitutive transport element) RNA of type D retroviruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Name: Nuclear RNA Export Factor 1
Chromosome: CHR11: 62559597 -62572964
Locus: 11q12.3
Gene Diseases
The SLC3A2 NXF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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