SEARCH OUR PRODUCT CATALOG

FISH Probe Products & Services
Request More Information

SLC2A13-TERT Fusion FISH Probe

The SLC2A13-TERT Fusion FISH Probe is used to confirm a fusion of the SLC2A13 and TERT genes. The fusion of the SLC2A13 and TERT genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
SLC2A13-TERT-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
SLC2A13-TERT-20-RERE 20 (40 μL) 200 μL
SLC2A13-TERT-20-REOR 20 (40 μL) 200 μL
SLC2A13-TERT-20-REGO 20 (40 μL) 200 μL
SLC2A13-TERT-20-REGR 20 (40 μL) 200 μL
SLC2A13-TERT-20-REAQ 20 (40 μL) 200 μL
SLC2A13-TERT-20-ORRE 20 (40 μL) 200 μL
SLC2A13-TERT-20-OROR 20 (40 μL) 200 μL
SLC2A13-TERT-20-ORGO 20 (40 μL) 200 μL
SLC2A13-TERT-20-ORAQ 20 (40 μL) 200 μL
SLC2A13-TERT-20-GORE 20 (40 μL) 200 μL
SLC2A13-TERT-20-GOOR 20 (40 μL) 200 μL
SLC2A13-TERT-20-GOGO 20 (40 μL) 200 μL
SLC2A13-TERT-20-GOGR 20 (40 μL) 200 μL
SLC2A13-TERT-20-GOAQ 20 (40 μL) 200 μL
SLC2A13-TERT-20-GRRE 20 (40 μL) 200 μL
SLC2A13-TERT-20-GROR 20 (40 μL) 200 μL
SLC2A13-TERT-20-GRGO 20 (40 μL) 200 μL
SLC2A13-TERT-20-GRGR 20 (40 μL) 200 μL
SLC2A13-TERT-20-GRAQ 20 (40 μL) 200 μL
SLC2A13-TERT-20-AQRE 20 (40 μL) 200 μL
SLC2A13-TERT-20-AQOR 20 (40 μL) 200 μL
SLC2A13-TERT-20-AQGO 20 (40 μL) 200 μL
SLC2A13-TERT-20-AQGR 20 (40 μL) 200 μL
SLC2A13-TERT-20-AQAQ 20 (40 μL) 200 μL

TERT Gene Summary

Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity. [provided by RefSeq, Jul 2008]

Gene Name: Telomerase Reverse Transcriptase

Chromosome: CHR5: 1253286 -1295162

Locus: 5p15.33

SLC2A13 Gene Summary

The Solute Carrier Family 2 Member 13 (SLC2A13) gene is located on chr12 :40148822-40499661 at 12q12.

Gene Name: Solute Carrier Family 2 Member 13

Chromosome: CHR12: 40148822 -40499661

Locus: 12q12

Gene Diseases

The SLC2A13 TERT Fusion has been associated with the following diseases:

Disease Name
Kidney Renal Clear Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure

Acral melanomas vary considerably in their molecular, histological, and clinical presentation. In this study, acral melanomas from dorsal, volar, and subungual-interdigital body sites were assessed using several tests, including FISH. Our TERT, CCND1, CDK4, AURKA, CDKN2A, PAK1, PTEN, NF1, and GAB2 probes were used to detect copy number variations in these genes. Genetic profiles were found to be tightly tied to UV exposure.
Read More

Distinct Patterns of Acral Melanoma Based on Site and Relative Sun Exposure

Acral melanomas vary considerably in their molecular, histological, and clinical presentation. In this study, acral melanomas from dorsal, volar, and subungual-interdigital body sites were assessed using several tests, including FISH. Our TERT, CCND1, CDK4, AURKA, CDKN2A, PAK1, PTEN, NF1, and GAB2 probes were used to detect copy number variations in these genes. Genetic profiles were found to be tightly tied to UV exposure.
Read More

Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines.

The TERT gene, which encodes a telomerase subunit, has long interested cancer researchers because it's required for cell proliferation and immortalization in 80-90% of human cancers. This study analyzed TERT expression across 10 human cancer lines using our TERT FISH probe. TERT expression was highly heterogeneous across different cancers, with variations in cellular location of the TERT protein, number of transcription sites, and ratio of transcription sites to gene copies.
Read More

Analysis of mucosal melanoma whole-genome landscapes reveals clinically relevant genomic aberrations

Unlike cutaneous melanoma, the genomics of mucosal melanoma (MM) remain poorly understood, which has hindered the development of targeted therapy for MM patients. In order to account for this gap in data, this team performed whole-genome sequencing on 65 MM samples to identify genomic alterations with prognostic and/or therapeutic implications. Our CDK4 and TERT probes were used to detect amplification of the genes.
Read More