SLC23A2-PHKB Fusion FISH Probe
The SLC23A2-PHKB Fusion FISH Probe is used to confirm a fusion of the SLC23A2 and PHKB genes. The fusion of the SLC23A2 and PHKB genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SLC23A2-PHKB-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-RERE | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-REOR | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-REGO | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-REGR | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-REAQ | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-ORRE | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-OROR | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-ORGO | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-ORAQ | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-GORE | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-GOOR | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-GOGO | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-GOGR | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-GOAQ | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-GRRE | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-GROR | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-GRGO | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-GRGR | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-GRAQ | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-AQRE | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-AQOR | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-AQGO | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-AQGR | 20 (40 μL) | 200 μL |
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| SLC23A2-PHKB-20-AQAQ | 20 (40 μL) | 200 μL |
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PHKB Gene Summary
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by this gene, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration. Mutations in this gene cause glycogen storage disease type 9B, also known as phosphorylase kinase deficiency of liver and muscle. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. Two pseudogenes have been found on chromosomes 14 and 20, respectively.[provided by RefSeq, Feb 2010]
Gene Name: Phosphorylase Kinase Regulatory Subunit Beta
Chromosome: CHR16: 47495209 -47735434
Locus: 16q12.1
SLC23A2 Gene Summary
The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq, Jul 2008]
Gene Name: Solute Carrier Family 23 Member 2
Chromosome: CHR20: 4833001 -4990939
Locus: 20p13
Gene Diseases
The SLC23A2 PHKB Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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