SKP1-PMPCA Fusion FISH Probe
The SKP1-PMPCA Fusion FISH Probe is used to confirm a fusion of the SKP1 and PMPCA genes. The fusion of the SKP1 and PMPCA genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SKP1-PMPCA-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-RERE | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-REOR | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-REGO | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-REGR | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-OROR | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-GORE | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-GROR | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| SKP1-PMPCA-20-AQAQ | 20 (40 μL) | 200 μL |
|
SKP1 Gene Summary
This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]
Gene Name: S-phase Kinase Associated Protein 1
Chromosome: CHR5: 133492081 -133512724
Locus: 5q31.1
PMPCA Gene Summary
The protein encoded by this gene is found in the mitochondrion, where it represents the alpha subunit of a proteolytic heterodimer. This heterodimer is responsible for cleaving the transit peptide from nuclear-encoded mitochondrial proteins. Defects in this gene are a cause of spinocerebellar ataxia, autosomal recessive 2. [provided by RefSeq, Mar 2016]
Gene Name: Peptidase, Mitochondrial Processing Alpha Subunit
Chromosome: CHR9: 139305115 -139318213
Locus: 9q34.3
Gene Diseases
The SKP1 PMPCA Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|