SKIV2L2-PCDHGB4 Fusion FISH Probe
The SKIV2L2-PCDHGB4 Fusion FISH Probe is used to confirm a fusion of the SKIV2L2 and PCDHGB4 genes. The fusion of the SKIV2L2 and PCDHGB4 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SKIV2L2-PCDHGB4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-RERE | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-REOR | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-REGO | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-REGR | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-REAQ | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-ORRE | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-OROR | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-ORGO | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-ORAQ | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-GORE | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-GOOR | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-GOGO | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-GOGR | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-GOAQ | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-GRRE | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-GROR | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-GRGO | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-GRGR | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-GRAQ | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-AQRE | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-AQOR | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-AQGO | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-AQGR | 20 (40 μL) | 200 μL |
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| SKIV2L2-PCDHGB4-20-AQAQ | 20 (40 μL) | 200 μL |
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PCDHGB4 Gene Summary
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
Gene Name: Protocadherin Gamma Subfamily B, 4
Chromosome: CHR5: 140767451 -140892546
Locus: 5q31.3
SKIV2L2 Gene Summary
The Ski2 Like RNA Helicase 2 (SKIV2L2) gene is located on chr5 :54603575-54721409 at 5q11.2.
Gene Name: Ski2 Like RNA Helicase 2
Chromosome: CHR5: 54603575 -54721409
Locus: 5q11.2
Gene Diseases
The SKIV2L2 PCDHGB4 Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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