SKIV2L-MSH5 Fusion FISH Probe
The SKIV2L-MSH5 Fusion FISH Probe is used to confirm a fusion of the SKIV2L and MSH5 genes. The fusion of the SKIV2L and MSH5 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SKIV2L-MSH5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-RERE | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-REOR | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-REGO | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-REGR | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-OROR | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-GORE | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-GROR | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| SKIV2L-MSH5-20-AQAQ | 20 (40 μL) | 200 μL |
|
MSH5 Gene Summary
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair and meiotic recombination. This protein is similar to a Saccharomyces cerevisiae protein that participates in segregation fidelity and crossing-over events during meiosis. This protein plays a role in promoting ionizing radiation-induced apoptosis. This protein forms hetero-oligomers with another member of this family, mutS homolog 4. Polymorphisms in this gene have been linked to various human diseases, including IgA deficiency, common variable immunodeficiency, and premature ovarian failure. Alternative splicing results multiple transcript variants. Read-through transcription also exists between this gene and the downstream chromosome 6 open reading frame 26 (C6orf26) gene. [provided by RefSeq, Feb 2011]
Gene Name: MutS Homolog 5
Chromosome: CHR6_mcf_hap5: 3087408 -3110152
Locus: 6p21.33
SKIV2L Gene Summary
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a human homologue of yeast SKI2 and may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene is located in the class III region of the major histocompatibility complex. [provided by RefSeq, Jul 2008]
Gene Name: Ski2 Like RNA Helicase
Chromosome: CHR6_ssto_hap7: 3259290 -3270242
Locus: 6p21.33
Gene Diseases
The SKIV2L MSH5 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|