SKIL-PRKCI Fusion FISH Probe
The SKIL-PRKCI Fusion FISH Probe is used to confirm a fusion of the SKIL and PRKCI genes. The fusion of the SKIL and PRKCI genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SKIL-PRKCI-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-RERE | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-REOR | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-REGO | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-REGR | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-REAQ | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-ORRE | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-OROR | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-ORGO | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-ORAQ | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-GORE | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-GOOR | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-GOGO | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-GOGR | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-GOAQ | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-GRRE | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-GROR | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-GRGO | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-GRGR | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-GRAQ | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-AQRE | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-AQOR | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-AQGO | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-AQGR | 20 (40 μL) | 200 μL |
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| SKIL-PRKCI-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKCI Gene Summary
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase C Iota
Chromosome: CHR3: 169940219 -170023770
Locus: 3q26.2
SKIL Gene Summary
The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: SKI Like Proto-oncogene
Chromosome: CHR3: 170075472 -170110950
Locus: 3q26.2
Gene Diseases
The SKIL PRKCI Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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