SKIL-FNDC3B Fusion FISH Probe
The SKIL-FNDC3B Fusion FISH Probe is used to confirm a fusion of the SKIL and FNDC3B genes. The fusion of the SKIL and FNDC3B genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SKIL-FNDC3B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-RERE | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-REOR | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-REGO | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-REGR | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-REAQ | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-ORRE | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-OROR | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-ORGO | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-ORAQ | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-GORE | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-GOOR | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-GOGO | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-GOGR | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-GOAQ | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-GRRE | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-GROR | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-GRGO | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-GRGR | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-GRAQ | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-AQRE | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-AQOR | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-AQGO | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-AQGR | 20 (40 μL) | 200 μL |
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| SKIL-FNDC3B-20-AQAQ | 20 (40 μL) | 200 μL |
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SKIL Gene Summary
The protein encoded by this gene is a component of the SMAD pathway, which regulates cell growth and differentiation through transforming growth factor-beta (TGFB). In the absence of ligand, the encoded protein binds to the promoter region of TGFB-responsive genes and recruits a nuclear repressor complex. TGFB signaling causes SMAD3 to enter the nucleus and degrade this protein, allowing these genes to be activated. Four transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Name: SKI Like Proto-oncogene
Chromosome: CHR3: 170075472 -170110950
Locus: 3q26.2
FNDC3B Gene Summary
The Fibronectin Type III Domain Containing 3B (FNDC3B) gene is located on chr3 :171757417-172118492 at 3q26.31.
Gene Name: Fibronectin Type III Domain Containing 3B
Chromosome: CHR3: 171757417 -172118492
Locus: 3q26.31
Gene Diseases
The SKIL FNDC3B Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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