SKI-PRKCZ Fusion FISH Probe
The SKI-PRKCZ Fusion FISH Probe is used to confirm a fusion of the SKI and PRKCZ genes. The fusion of the SKI and PRKCZ genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SKI-PRKCZ-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-RERE | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-REOR | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-REGO | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-REGR | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-REAQ | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-ORRE | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-OROR | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-ORGO | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-ORAQ | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-GORE | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-GOOR | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-GOGO | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-GOGR | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-GOAQ | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-GRRE | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-GROR | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-GRGO | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-GRGR | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-GRAQ | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-AQRE | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-AQOR | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-AQGO | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-AQGR | 20 (40 μL) | 200 μL |
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| SKI-PRKCZ-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKCZ Gene Summary
Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase C Zeta
Chromosome: CHR1: 1981908 -2116834
Locus: 1p36.33
SKI Gene Summary
This gene encodes the nuclear protooncogene protein homolog of avian sarcoma viral (v-ski) oncogene. It functions as a repressor of TGF-beta signaling, and may play a role in neural tube development and muscle differentiation. [provided by RefSeq, Oct 2009]
Gene Name: SKI Proto-oncogene
Chromosome: CHR1: 2160133 -2241652
Locus: 1p36.33-p36.32
Gene Diseases
The SKI PRKCZ Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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