SKAP1-PSMD11 Fusion FISH Probe
The SKAP1-PSMD11 Fusion FISH Probe is used to confirm a fusion of the SKAP1 and PSMD11 genes. The fusion of the SKAP1 and PSMD11 genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SKAP1-PSMD11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-RERE | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-REOR | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-REGO | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-REGR | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-REAQ | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-ORRE | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-OROR | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-ORGO | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-ORAQ | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-GORE | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-GOOR | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-GOGO | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-GOGR | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-GOAQ | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-GRRE | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-GROR | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-GRGO | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-GRGR | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-GRAQ | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-AQRE | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-AQOR | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-AQGO | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-AQGR | 20 (40 μL) | 200 μL |
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| SKAP1-PSMD11-20-AQAQ | 20 (40 μL) | 200 μL |
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PSMD11 Gene Summary
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. This gene encodes a member of the proteasome subunit S9 family that functions as a non-ATPase subunit of the 19S regulator and is phosphorylated by AMP-activated protein kinase. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Proteasome 26S Subunit, Non-ATPase 11
Chromosome: CHR17: 30771501 -30808042
Locus: 17q11.2
SKAP1 Gene Summary
This gene encodes a T cell adaptor protein, a class of intracellular molecules with modular domains capable of recruiting additional proteins but that exhibit no intrinsic enzymatic activity. The encoded protein contains a unique N-terminal region followed by a PH domain and C-terminal SH3 domain. Along with the adhesion and degranulation-promoting adaptor protein, the encoded protein plays a critical role in inside-out signaling by coupling T-cell antigen receptor stimulation to the activation of integrins. [provided by RefSeq, Jul 2008]
Gene Name: Src Kinase Associated Phosphoprotein 1
Chromosome: CHR17: 46210801 -46507594
Locus: 17q21.32
Gene Diseases
The SKAP1 PSMD11 Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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