SIRT1-DNAJC12 Fusion FISH Probe
The SIRT1-DNAJC12 Fusion FISH Probe is used to confirm a fusion of the SIRT1 and DNAJC12 genes. The fusion of the SIRT1 and DNAJC12 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SIRT1-DNAJC12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-RERE | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-REOR | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-REGO | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-REGR | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-REAQ | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-ORRE | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-OROR | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-ORGO | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-ORAQ | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-GORE | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-GOOR | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-GOGO | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-GOGR | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-GOAQ | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-GRRE | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-GROR | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-GRGO | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-GRGR | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-GRAQ | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-AQRE | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-AQOR | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-AQGO | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-AQGR | 20 (40 μL) | 200 μL |
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| SIRT1-DNAJC12-20-AQAQ | 20 (40 μL) | 200 μL |
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SIRT1 Gene Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Gene Name: Sirtuin 1
Chromosome: CHR10: 69644426 -69678147
Locus: 10q21.3
DNAJC12 Gene Summary
This gene encodes a member of a subclass of the HSP40/DnaJ protein family. Members of this family of proteins are associated with complex assembly, protein folding, and export. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Name: DnaJ Heat Shock Protein Family (Hsp40) Member C12
Chromosome: CHR10: 69556426 -69597937
Locus: 10q21.3
Gene Diseases
The SIRT1 DNAJC12 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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