SIPA1L3-LSM14A Fusion FISH Probe
The SIPA1L3-LSM14A Fusion FISH Probe is used to confirm a fusion of the SIPA1L3 and LSM14A genes. The fusion of the SIPA1L3 and LSM14A genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SIPA1L3-LSM14A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-RERE | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-REOR | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-REGO | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-REGR | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-REAQ | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-ORRE | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-OROR | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-ORGO | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-ORAQ | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-GORE | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-GOOR | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-GOGO | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-GOGR | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-GOAQ | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-GRRE | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-GROR | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-GRGO | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-GRGR | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-GRAQ | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-AQRE | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-AQOR | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-AQGO | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-AQGR | 20 (40 μL) | 200 μL |
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| SIPA1L3-LSM14A-20-AQAQ | 20 (40 μL) | 200 μL |
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SIPA1L3 Gene Summary
This gene belongs to the signal induced proliferation associated 1 family of genes, which encode GTPase-activating proteins specific for the GTP-binding protein Rap1. Rap1 has been implicated in regulation of cell adhesion, cell polarity, and organization of the cytoskeleton. Like other members of the family, the protein encoded by this gene contains RapGAP and PDZ domains. In addition, this protein contains a C-terminal leucine zipper domain. This gene is proposed to function in epithelial cell morphogenesis and establishment or maintenance of polarity. Consistently, expression of the protein in cell culture showed localization to cell-cell borders in apical regions, and downregulation of the gene in 3D Caco2 cell culture resulted in abnormal cell polarity and morphogenesis. Allelic variants of this gene have been associated with congenital cataracts in humans. [provided by RefSeq, Feb 2016]
Gene Name: Signal Induced Proliferation Associated 1 Like 3
Chromosome: CHR19: 38397867 -38699008
Locus: 19q13.13-q13.2
LSM14A Gene Summary
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]
Gene Name: LSM14A, MRNA Processing Body Assembly Factor
Chromosome: CHR19: 34663351 -34720420
Locus: 19q13.11
Gene Diseases
The SIPA1L3 LSM14A Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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