SIPA1L3-GPI Fusion FISH Probe
The SIPA1L3-GPI Fusion FISH Probe is used to confirm a fusion of the SIPA1L3 and GPI genes. The fusion of the SIPA1L3 and GPI genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SIPA1L3-GPI-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-RERE | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-REOR | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-REGO | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-REGR | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-REAQ | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-ORRE | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-OROR | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-ORGO | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-ORAQ | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-GORE | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-GOOR | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-GOGO | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-GOGR | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-GOAQ | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-GRRE | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-GROR | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-GRGO | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-GRGR | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-GRAQ | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-AQRE | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-AQOR | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-AQGO | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-AQGR | 20 (40 μL) | 200 μL |
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| SIPA1L3-GPI-20-AQAQ | 20 (40 μL) | 200 μL |
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GPI Gene Summary
This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Gene Name: Glucose-6-phosphate Isomerase
Chromosome: CHR19: 34855644 -34893318
Locus: 19q13.11
SIPA1L3 Gene Summary
This gene belongs to the signal induced proliferation associated 1 family of genes, which encode GTPase-activating proteins specific for the GTP-binding protein Rap1. Rap1 has been implicated in regulation of cell adhesion, cell polarity, and organization of the cytoskeleton. Like other members of the family, the protein encoded by this gene contains RapGAP and PDZ domains. In addition, this protein contains a C-terminal leucine zipper domain. This gene is proposed to function in epithelial cell morphogenesis and establishment or maintenance of polarity. Consistently, expression of the protein in cell culture showed localization to cell-cell borders in apical regions, and downregulation of the gene in 3D Caco2 cell culture resulted in abnormal cell polarity and morphogenesis. Allelic variants of this gene have been associated with congenital cataracts in humans. [provided by RefSeq, Feb 2016]
Gene Name: Signal Induced Proliferation Associated 1 Like 3
Chromosome: CHR19: 38397867 -38699008
Locus: 19q13.13-q13.2
Gene Diseases
The SIPA1L3 GPI Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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