SIPA1-RHOD Fusion FISH Probe
The SIPA1-RHOD Fusion FISH Probe is used to confirm a fusion of the SIPA1 and RHOD genes. The fusion of the SIPA1 and RHOD genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SIPA1-RHOD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-RERE | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-REOR | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-REGO | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-REGR | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-REAQ | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-ORRE | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-OROR | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-ORGO | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-ORAQ | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-GORE | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-GOOR | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-GOGO | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-GOGR | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-GOAQ | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-GRRE | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-GROR | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-GRGO | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-GRGR | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-GRAQ | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-AQRE | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-AQOR | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-AQGO | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-AQGR | 20 (40 μL) | 200 μL |
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| SIPA1-RHOD-20-AQAQ | 20 (40 μL) | 200 μL |
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SIPA1 Gene Summary
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date. [provided by RefSeq, Jul 2008]
Gene Name: Signal-induced Proliferation-associated 1
Chromosome: CHR11: 65405577 -65418391
Locus: 11q13.1
RHOD Gene Summary
Ras homolog, or Rho, proteins interact with protein kinases and may serve as targets for activated GTPase. They play a critical role in muscle differentiation. The protein encoded by this gene binds GTP and is a member of the small GTPase superfamily. It is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane transport with the function of the cytoskeleton. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Name: Ras Homolog Family Member D
Chromosome: CHR11: 66824288 -66839488
Locus: 11q13.2
Gene Diseases
The SIPA1 RHOD Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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