SIN3A-PTPN9 Fusion FISH Probe
The SIN3A-PTPN9 Fusion FISH Probe is used to confirm a fusion of the SIN3A and PTPN9 genes. The fusion of the SIN3A and PTPN9 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SIN3A-PTPN9-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-RERE | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-REOR | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-REGO | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-REGR | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-REAQ | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-ORRE | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-OROR | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-ORGO | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-ORAQ | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-GORE | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-GOOR | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-GOGO | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-GOGR | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-GOAQ | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-GRRE | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-GROR | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-GRGO | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-GRGR | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-GRAQ | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-AQRE | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-AQOR | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-AQGO | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-AQGR | 20 (40 μL) | 200 μL |
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| SIN3A-PTPN9-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPN9 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by polyphosphoinositide, and is thought to be involved in signaling events regulating phagocytosis. [provided by RefSeq, Jul 2008]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 9
Chromosome: CHR15: 75759461 -75871625
Locus: 15q24.2
SIN3A Gene Summary
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex. [provided by RefSeq, Jul 2008]
Gene Name: SIN3 Transcription Regulator Family Member A
Chromosome: CHR15: 75661719 -75748124
Locus: 15q24.2
Gene Diseases
The SIN3A PTPN9 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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