SIM2-MORC3 Fusion FISH Probe
The SIM2-MORC3 Fusion FISH Probe is used to confirm a fusion of the SIM2 and MORC3 genes. The fusion of the SIM2 and MORC3 genes has been associated with Esophageal Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SIM2-MORC3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-RERE | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-REOR | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-REGO | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-REGR | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-REAQ | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-ORRE | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-OROR | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-ORGO | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-ORAQ | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-GORE | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-GOOR | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-GOGO | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-GOGR | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-GOAQ | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-GRRE | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-GROR | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-GRGO | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-GRGR | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-GRAQ | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-AQRE | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-AQOR | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-AQGO | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-AQGR | 20 (40 μL) | 200 μL |
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| SIM2-MORC3-20-AQAQ | 20 (40 μL) | 200 μL |
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SIM2 Gene Summary
This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Gene Name: Single-minded Family BHLH Transcription Factor 2
Chromosome: CHR21: 38071990 -38122510
Locus: 21q22.13
MORC3 Gene Summary
This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]
Gene Name: MORC Family CW-type Zinc Finger 3
Chromosome: CHR21: 37692486 -37748944
Locus: 21q22.12
Gene Diseases
The SIM2 MORC3 Fusion has been associated with the following diseases:
| Disease Name |
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| Esophageal Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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