SIM2-KCNJ6 Fusion FISH Probe
The SIM2-KCNJ6 Fusion FISH Probe is used to confirm a fusion of the SIM2 and KCNJ6 genes. The fusion of the SIM2 and KCNJ6 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SIM2-KCNJ6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-RERE | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-REOR | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-REGO | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-REGR | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-REAQ | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-ORRE | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-OROR | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-ORGO | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-ORAQ | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-GORE | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-GOOR | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-GOGO | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-GOGR | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-GOAQ | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-GRRE | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-GROR | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-GRGO | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-GRGR | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-GRAQ | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-AQRE | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-AQOR | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-AQGO | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-AQGR | 20 (40 μL) | 200 μL |
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| SIM2-KCNJ6-20-AQAQ | 20 (40 μL) | 200 μL |
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KCNJ6 Gene Summary
This gene encodes a member of the G protein-coupled inwardly-rectifying potassium channel family of inward rectifier potassium channels. This type of potassium channel allows a greater flow of potassium into the cell than out of it. These proteins modulate many physiological processes, including heart rate in cardiac cells and circuit activity in neuronal cells, through G-protein coupled receptor stimulation. Mutations in this gene are associated with Keppen-Lubinsky Syndrome, a rare condition characterized by severe developmental delay, facial dysmorphism, and intellectual disability. [provided by RefSeq, Apr 2015]
Gene Name: Potassium Voltage-gated Channel Subfamily J Member 6
Chromosome: CHR21: 38996785 -39288696
Locus: 21q22.13
SIM2 Gene Summary
This gene represents a homolog of the Drosophila single-minded (sim) gene, which encodes a transcription factor that is a master regulator of neurogenesis. The encoded protein is ubiquitinated by RING-IBR-RING-type E3 ubiquitin ligases, including the parkin RBR E3 ubiquitin protein ligase. This gene maps within the so-called Down syndrome chromosomal region, and is thus thought to contribute to some specific Down syndrome phenotypes. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Gene Name: Single-minded Family BHLH Transcription Factor 2
Chromosome: CHR21: 38071990 -38122510
Locus: 21q22.13
Gene Diseases
The SIM2 KCNJ6 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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