SHROOM4-AR Fusion FISH Probe
The SHROOM4-AR Fusion FISH Probe is used to confirm a fusion of the SHROOM4 and AR genes. The fusion of the SHROOM4 and AR genes has been associated with Cholangiocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SHROOM4-AR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-RERE | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-REOR | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-REGO | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-REGR | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-REAQ | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-ORRE | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-OROR | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-ORGO | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-ORAQ | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-GORE | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-GOOR | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-GOGO | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-GOGR | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-GOAQ | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-GRRE | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-GROR | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-GRGO | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-GRGR | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-GRAQ | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-AQRE | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-AQOR | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-AQGO | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-AQGR | 20 (40 μL) | 200 μL |
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| SHROOM4-AR-20-AQAQ | 20 (40 μL) | 200 μL |
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AR Gene Summary
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
Gene Name: Androgen Receptor
Chromosome: CHRX: 66763873 -66944119
Locus: Xq12
SHROOM4 Gene Summary
This gene encodes a member of the APX/Shroom family, which contain an N-terminal PDZ domain and a C-terminal ASD2 motif. The encoded protein may play a role in cytoskeletal architecture. Mutations in this gene have been linked to the X-linked Stocco dos Santos syndrome characterized by cognitive disabilities. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2017]
Gene Name: Shroom Family Member 4
Chromosome: CHRX: 50334642 -50557044
Locus: Xp11.22
Gene Diseases
The SHROOM4 AR Fusion has been associated with the following diseases:
| Disease Name |
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| Cholangiocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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