SHPK-GUCY1A2 Fusion FISH Probe
The SHPK-GUCY1A2 Fusion FISH Probe is used to confirm a fusion of the SHPK and GUCY1A2 genes. The fusion of the SHPK and GUCY1A2 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SHPK-GUCY1A2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-RERE | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-REOR | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-REGO | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-REGR | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-REAQ | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-ORRE | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-OROR | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-ORGO | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-GORE | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-GOOR | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-GOGO | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-GOGR | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-GRRE | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-GROR | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-GRGO | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-GRGR | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-AQRE | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-AQOR | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-AQGO | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-AQGR | 20 (40 μL) | 200 μL |
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| SHPK-GUCY1A2-20-AQAQ | 20 (40 μL) | 200 μL |
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GUCY1A2 Gene Summary
Soluble guanylate cyclases are heterodimeric proteins that catalyze the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein encoded by this gene is an alpha subunit of this complex and it interacts with a beta subunit to form the guanylate cyclase enzyme, which is activated by nitric oxide. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Gene Name: Guanylate Cyclase 1 Soluble Subunit Alpha 2
Chromosome: CHR11: 106557909 -106889171
Locus: 11q22.3
SHPK Gene Summary
The protein encoded by this gene has weak homology to several carbohydrate kinases, a class of proteins involved in the phosphorylation of sugars as they enter a cell, inhibiting return across the cell membrane. Sequence variation between this novel gene and known carbohydrate kinases suggests the possibility of a different substrate, cofactor or changes in kinetic properties distinguishing it from other carbohydrate kinases. The gene resides in a region commonly deleted in cystinosis patients, suggesting a role as a modifier for the cystinosis phenotype. The genomic region is also rich in Alu repetitive sequences, frequently involved in chromosomal rearrangements. [provided by RefSeq, Jul 2008]
Gene Name: Sedoheptulokinase
Chromosome: CHR17: 3511555 -3539616
Locus: 17p13.2
Gene Diseases
The SHPK GUCY1A2 Fusion has been associated with the following diseases:
| Disease Name |
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| Bladder Urothelial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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