SHH-PLCB1 Fusion FISH Probe
The SHH-PLCB1 Fusion FISH Probe is used to confirm a fusion of the SHH and PLCB1 genes. The fusion of the SHH and PLCB1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SHH-PLCB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-RERE | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-REOR | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-REGO | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-REGR | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-REAQ | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-ORRE | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-OROR | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-ORGO | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-GORE | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-GOOR | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-GOGO | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-GOGR | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-GRRE | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-GROR | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-GRGO | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-GRGR | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-AQRE | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-AQOR | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-AQGO | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-AQGR | 20 (40 μL) | 200 μL |
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| SHH-PLCB1-20-AQAQ | 20 (40 μL) | 200 μL |
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SHH Gene Summary
This gene encodes a protein that is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo. Defects in this protein or in its signalling pathway are a cause of holoprosencephaly (HPE), a disorder in which the developing forebrain fails to correctly separate into right and left hemispheres. HPE is manifested by facial deformities. It is also thought that mutations in this gene or in its signalling pathway may be responsible for VACTERL syndrome, which is characterized by vertebral defects, anal atresia, tracheoesophageal fistula with esophageal atresia, radial and renal dysplasia, cardiac anomalies, and limb abnormalities. Additionally, mutations in a long range enhancer located approximately 1 megabase upstream of this gene disrupt limb patterning and can result in preaxial polydactyly. [provided by RefSeq, Jul 2008]
Gene Name: Sonic Hedgehog
Chromosome: CHR7: 155595557 -155604967
Locus: 7q36.3
PLCB1 Gene Summary
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Phospholipase C Beta 1
Chromosome: CHR20: 8113295 -8865547
Locus: 20p12.3
Gene Diseases
The SHH PLCB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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