SHC2-TJP3 Fusion FISH Probe
The SHC2-TJP3 Fusion FISH Probe is used to confirm a fusion of the SHC2 and TJP3 genes. The fusion of the SHC2 and TJP3 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SHC2-TJP3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-RERE | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-REOR | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-REGO | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-REGR | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-REAQ | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-ORRE | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-OROR | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-ORGO | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-ORAQ | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-GORE | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-GOOR | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-GOGO | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-GOGR | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-GOAQ | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-GRRE | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-GROR | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-GRGO | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-GRGR | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-GRAQ | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-AQRE | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-AQOR | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-AQGO | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-AQGR | 20 (40 μL) | 200 μL |
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| SHC2-TJP3-20-AQAQ | 20 (40 μL) | 200 μL |
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SHC2 Gene Summary
The SHC Adaptor Protein 2 (SHC2) gene is located on chr19 :416582-460996 at 19p13.3.
Gene Name: SHC Adaptor Protein 2
Chromosome: CHR19: 416582 -460996
Locus: 19p13.3
TJP3 Gene Summary
The protein encoded by this gene is a member of the membrane-associated guanylate kinase-like (MAGUK) protein family which is characterized by members having multiple PDZ domains, a single SH3 domain, and a single guanylate kinase-like (GUK)-domain. In addition, members of the zonula occludens protein subfamily have an acidic domain, a basic arginine-rich region, and a proline-rich domain. The protein encoded by this gene plays a role in the linkage between the actin cytoskeleton and tight-junctions and also sequesters cyclin D1 at tight junctions during mitosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms. This gene has a partial pseudogene on chromosome 1. [provided by RefSeq, May 2012]
Gene Name: Tight Junction Protein 3
Chromosome: CHR19: 3728373 -3750682
Locus: 19p13.3
Gene Diseases
The SHC2 TJP3 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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