SHC1-FOXP1 Fusion FISH Probe
The SHC1-FOXP1 Fusion FISH Probe is used to confirm a fusion of the SHC1 and FOXP1 genes. The fusion of the SHC1 and FOXP1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SHC1-FOXP1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-RERE | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-REOR | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-REGO | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-REGR | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-REAQ | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-ORRE | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-OROR | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-ORGO | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-GORE | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-GOOR | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-GOGO | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-GOGR | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-GRRE | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-GROR | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-GRGO | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-GRGR | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-AQRE | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-AQOR | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-AQGO | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-AQGR | 20 (40 μL) | 200 μL |
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| SHC1-FOXP1-20-AQAQ | 20 (40 μL) | 200 μL |
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SHC1 Gene Summary
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Gene Name: SHC Adaptor Protein 1
Chromosome: CHR1: 154934773 -154946959
Locus: 1q21.3
FOXP1 Gene Summary
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Forkhead Box P1
Chromosome: CHR3: 71004735 -71633140
Locus: 3p13
Gene Diseases
The SHC1 FOXP1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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