SHC1-ASH1L Fusion FISH Probe
The SHC1-ASH1L Fusion FISH Probe is used to confirm a fusion of the SHC1 and ASH1L genes. The fusion of the SHC1 and ASH1L genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SHC1-ASH1L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-RERE | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-REOR | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-REGO | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-REGR | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-REAQ | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-ORRE | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-OROR | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-ORGO | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-ORAQ | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-GORE | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-GOOR | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-GOGO | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-GOGR | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-GOAQ | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-GRRE | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-GROR | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-GRGO | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-GRGR | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-GRAQ | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-AQRE | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-AQOR | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-AQGO | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-AQGR | 20 (40 μL) | 200 μL |
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| SHC1-ASH1L-20-AQAQ | 20 (40 μL) | 200 μL |
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SHC1 Gene Summary
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Gene Name: SHC Adaptor Protein 1
Chromosome: CHR1: 154934773 -154946959
Locus: 1q21.3
ASH1L Gene Summary
This gene encodes a member of the trithorax group of transcriptional activators. The protein contains four AT hooks, a SET domain, a PHD-finger motif, and a bromodomain. It is localized to many small speckles in the nucleus, and also to cell-cell tight junctions. [provided by RefSeq, Jul 2008]
Gene Name: ASH1 Like Histone Lysine Methyltransferase
Chromosome: CHR1: 155305051 -155532324
Locus: 1q22
Gene Diseases
The SHC1 ASH1L Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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