SHB-CDKN2A Fusion FISH Probe
The SHB-CDKN2A Fusion FISH Probe is used to confirm a fusion of the SHB and CDKN2A genes. The fusion of the SHB and CDKN2A genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SHB-CDKN2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-RERE | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-REOR | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-REGO | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-REGR | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-REAQ | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-ORRE | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-OROR | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-ORGO | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-GORE | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-GOOR | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-GOGO | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-GOGR | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-GRRE | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-GROR | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-GRGO | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-GRGR | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-AQRE | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-AQOR | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-AQGO | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-AQGR | 20 (40 μL) | 200 μL |
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| SHB-CDKN2A-20-AQAQ | 20 (40 μL) | 200 μL |
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CDKN2A Gene Summary
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
Gene Name: Cyclin Dependent Kinase Inhibitor 2A
Chromosome: CHR9: 21967750 -21994490
Locus: 9p21.3
SHB Gene Summary
The SH2 Domain Containing Adaptor Protein B (SHB) gene is located on chr9 :37915894-38069210 at 9p13.1.
Gene Name: SH2 Domain Containing Adaptor Protein B
Chromosome: CHR9: 37915894 -38069210
Locus: 9p13.1
Gene Diseases
The SHB CDKN2A Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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