SHANK3-PLXNB2 Fusion FISH Probe
The SHANK3-PLXNB2 Fusion FISH Probe is used to confirm a fusion of the SHANK3 and PLXNB2 genes. The fusion of the SHANK3 and PLXNB2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SHANK3-PLXNB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-RERE | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-REOR | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-REGO | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-REGR | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-REAQ | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-ORRE | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-OROR | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-ORGO | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-GORE | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-GOOR | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-GOGO | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-GOGR | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-GRRE | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-GROR | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-GRGO | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-GRGR | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-AQRE | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-AQOR | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-AQGO | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-AQGR | 20 (40 μL) | 200 μL |
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| SHANK3-PLXNB2-20-AQAQ | 20 (40 μL) | 200 μL |
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PLXNB2 Gene Summary
Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]
Gene Name: Plexin B2
Chromosome: CHR22: 50713407 -50746001
Locus: 22q13.33
SHANK3 Gene Summary
This gene is a member of the Shank gene family. Shank proteins are multidomain scaffold proteins of the postsynaptic density that connect neurotransmitter receptors, ion channels, and other membrane proteins to the actin cytoskeleton and G-protein-coupled signaling pathways. Shank proteins also play a role in synapse formation and dendritic spine maturation. Mutations in this gene are a cause of autism spectrum disorder (ASD), which is characterized by impairments in social interaction and communication, and restricted behavioral patterns and interests. Mutations in this gene also cause schizophrenia type 15, and are a major causative factor in the neurological symptoms of 22q13.3 deletion syndrome, which is also known as Phelan-McDermid syndrome. Additional isoforms have been described for this gene but they have not yet been experimentally verified. [provided by RefSeq, Mar 2012]
Gene Name: SH3 And Multiple Ankyrin Repeat Domains 3
Chromosome: CHR22: 51113069 -51171641
Locus: 22q13.33
Gene Diseases
The SHANK3 PLXNB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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