SHANK2-WNT11 Fusion FISH Probe
The SHANK2-WNT11 Fusion FISH Probe is used to confirm a fusion of the SHANK2 and WNT11 genes. The fusion of the SHANK2 and WNT11 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SHANK2-WNT11-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-RERE | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-REOR | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-REGO | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-REGR | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-REAQ | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-ORRE | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-OROR | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-ORGO | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-ORAQ | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-GORE | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-GOOR | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-GOGO | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-GOGR | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-GOAQ | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-GRRE | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-GROR | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-GRGO | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-GRGR | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-GRAQ | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-AQRE | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-AQOR | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-AQGO | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-AQGR | 20 (40 μL) | 200 μL |
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| SHANK2-WNT11-20-AQAQ | 20 (40 μL) | 200 μL |
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WNT11 Gene Summary
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008]
Gene Name: Wnt Family Member 11
Chromosome: CHR11: 75897369 -75917574
Locus: 11q13.5
SHANK2 Gene Summary
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Name: SH3 And Multiple Ankyrin Repeat Domains 2
Chromosome: CHR11: 70313960 -70935808
Locus: 11q13.3-q13.4
Gene Diseases
The SHANK2 WNT11 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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