SHANK2-ITPK1 Fusion FISH Probe
The SHANK2-ITPK1 Fusion FISH Probe is used to confirm a fusion of the SHANK2 and ITPK1 genes. The fusion of the SHANK2 and ITPK1 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SHANK2-ITPK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-RERE | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-REOR | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-REGO | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-REGR | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-REAQ | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-ORRE | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-OROR | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-ORGO | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-GORE | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-GOOR | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-GOGO | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-GOGR | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-GRRE | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-GROR | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-GRGO | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-GRGR | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-AQRE | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-AQOR | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-AQGO | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-AQGR | 20 (40 μL) | 200 μL |
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| SHANK2-ITPK1-20-AQAQ | 20 (40 μL) | 200 μL |
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ITPK1 Gene Summary
This gene encodes an enzyme that belongs to the inositol 1,3,4-trisphosphate 5/6-kinase family. This enzyme regulates the synthesis of inositol tetraphosphate, and downstream products, inositol pentakisphosphate and inositol hexakisphosphate. Inositol metabolism plays a role in the development of the neural tube. Disruptions in this gene are thought to be associated with neural tube defects. A pseudogene of this gene has been identified on chromosome X. [provided by RefSeq, Jul 2016]
Gene Name: Inositol-tetrakisphosphate 1-kinase
Chromosome: CHR14: 93403258 -93582263
Locus: 14q32.12
SHANK2 Gene Summary
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Gene Name: SH3 And Multiple Ankyrin Repeat Domains 2
Chromosome: CHR11: 70313960 -70935808
Locus: 11q13.3-q13.4
Gene Diseases
The SHANK2 ITPK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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