SH3RF1-NEK1 Fusion FISH Probe
The SH3RF1-NEK1 Fusion FISH Probe is used to confirm a fusion of the SH3RF1 and NEK1 genes. The fusion of the SH3RF1 and NEK1 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SH3RF1-NEK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-RERE | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-REOR | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-REGO | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-REGR | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-REAQ | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-ORRE | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-OROR | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-ORGO | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-GORE | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-GOOR | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-GOGO | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-GOGR | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-GRRE | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-GROR | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-GRGO | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-GRGR | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-AQRE | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-AQOR | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-AQGO | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-AQGR | 20 (40 μL) | 200 μL |
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| SH3RF1-NEK1-20-AQAQ | 20 (40 μL) | 200 μL |
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NEK1 Gene Summary
The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Gene Name: NIMA Related Kinase 1
Chromosome: CHR4: 170314420 -170533778
Locus: 4q33
SH3RF1 Gene Summary
This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module. [provided by RefSeq, Jul 2008]
Gene Name: SH3 Domain Containing Ring Finger 1
Chromosome: CHR4: 170015406 -170192249
Locus: 4q32.3-q33
Gene Diseases
The SH3RF1 NEK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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