SH3BGRL-CBS Fusion FISH Probe
The SH3BGRL-CBS Fusion FISH Probe is used to confirm a fusion of the SH3BGRL and CBS genes. The fusion of the SH3BGRL and CBS genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SH3BGRL-CBS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-RERE | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-REOR | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-REGO | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-REGR | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-REAQ | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-ORRE | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-OROR | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-ORGO | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-ORAQ | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-GORE | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-GOOR | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-GOGO | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-GOGR | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-GOAQ | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-GRRE | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-GROR | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-GRGO | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-GRGR | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-GRAQ | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-AQRE | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-AQOR | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-AQGO | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-AQGR | 20 (40 μL) | 200 μL |
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| SH3BGRL-CBS-20-AQAQ | 20 (40 μL) | 200 μL |
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CBS Gene Summary
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. This gene is a major contributor to cellular hydrogen sulfide production. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]
Gene Name: Cystathionine-beta-synthase
Chromosome: CHR21: 44473300 -44496472
Locus: 21q22.3
SH3BGRL Gene Summary
The SH3 Domain Binding Glutamate Rich Protein Like (SH3BGRL) gene is located on chrX :80457302-80554046 at Xq21.1.
Gene Name: SH3 Domain Binding Glutamate Rich Protein Like
Chromosome: CHRX: 80457302 -80554046
Locus: Xq21.1
Gene Diseases
The SH3BGRL CBS Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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