SH2B3-CUX2 Fusion FISH Probe
The SH2B3-CUX2 Fusion FISH Probe is used to confirm a fusion of the SH2B3 and CUX2 genes. The fusion of the SH2B3 and CUX2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SH2B3-CUX2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-RERE | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-REOR | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-REGO | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-REGR | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-REAQ | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-ORRE | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-OROR | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-ORGO | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-GORE | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-GOOR | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-GOGO | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-GOGR | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-GRRE | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-GROR | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-GRGO | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-GRGR | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-AQRE | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-AQOR | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-AQGO | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-AQGR | 20 (40 μL) | 200 μL |
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| SH2B3-CUX2-20-AQAQ | 20 (40 μL) | 200 μL |
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SH2B3 Gene Summary
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Gene Name: SH2B Adaptor Protein 3
Chromosome: CHR12: 111843751 -111889427
Locus: 12q24.12
CUX2 Gene Summary
This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013]
Gene Name: Cut Like Homeobox 2
Chromosome: CHR12: 111471827 -111788358
Locus: 12q24.11-q24.12
Gene Diseases
The SH2B3 CUX2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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