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SFPQ-TFE3 Fusion FISH Probe

The SFPQ-TFE3 Fusion FISH Probe is used to confirm a fusion of the SFPQ and TFE3 genes. The fusion of the SFPQ and TFE3 genes has been associated with Kidney Renal Clear Cell Carcinoma, Kidney Renal Clear Cell Carcinoma, Kidney Renal Clear Cell Carcinoma, Kidney Renal Clear Cell Carcinoma, Kidney Renal Clear Cell Carcinoma, Kidney Renal Papillary Cell Carcinoma, and Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
SFPQ-TFE3-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
SFPQ-TFE3-20-RERE 20 (40 μL) 200 μL
SFPQ-TFE3-20-REOR 20 (40 μL) 200 μL
SFPQ-TFE3-20-REGO 20 (40 μL) 200 μL
SFPQ-TFE3-20-REGR 20 (40 μL) 200 μL
SFPQ-TFE3-20-REAQ 20 (40 μL) 200 μL
SFPQ-TFE3-20-ORRE 20 (40 μL) 200 μL
SFPQ-TFE3-20-OROR 20 (40 μL) 200 μL
SFPQ-TFE3-20-ORGO 20 (40 μL) 200 μL
SFPQ-TFE3-20-ORAQ 20 (40 μL) 200 μL
SFPQ-TFE3-20-GORE 20 (40 μL) 200 μL
SFPQ-TFE3-20-GOOR 20 (40 μL) 200 μL
SFPQ-TFE3-20-GOGO 20 (40 μL) 200 μL
SFPQ-TFE3-20-GOGR 20 (40 μL) 200 μL
SFPQ-TFE3-20-GOAQ 20 (40 μL) 200 μL
SFPQ-TFE3-20-GRRE 20 (40 μL) 200 μL
SFPQ-TFE3-20-GROR 20 (40 μL) 200 μL
SFPQ-TFE3-20-GRGO 20 (40 μL) 200 μL
SFPQ-TFE3-20-GRGR 20 (40 μL) 200 μL
SFPQ-TFE3-20-GRAQ 20 (40 μL) 200 μL
SFPQ-TFE3-20-AQRE 20 (40 μL) 200 μL
SFPQ-TFE3-20-AQOR 20 (40 μL) 200 μL
SFPQ-TFE3-20-AQGO 20 (40 μL) 200 μL
SFPQ-TFE3-20-AQGR 20 (40 μL) 200 μL
SFPQ-TFE3-20-AQAQ 20 (40 μL) 200 μL

SFPQ Gene Summary

The Splicing Factor Proline And Glutamine Rich (SFPQ) gene is located on chr1 :35649200-35658743 at 1p34.3.

Gene Name: Splicing Factor Proline And Glutamine Rich

Chromosome: CHR1: 35649200 -35658743

Locus: 1p34.3

TFE3 Gene Summary

This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Gene Name: Transcription Factor Binding To IGHM Enhancer 3

Chromosome: CHRX: 48886241 -48900990

Locus: Xp11.23

Gene Diseases

The SFPQ TFE3 Fusion has been associated with the following diseases:

Disease Name
Kidney Renal Clear Cell Carcinoma
Kidney Renal Clear Cell Carcinoma
Kidney Renal Clear Cell Carcinoma
Kidney Renal Clear Cell Carcinoma
Kidney Renal Clear Cell Carcinoma
Kidney Renal Papillary Cell Carcinoma
Kidney Renal Papillary Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Detection of 6 TFEB-amplified renal cell carcinomas and 25 renal cell carcinomas with MITF translocations: systematic morphologic analysis of 85 cases evaluated by clinical TFE3 and TFEB FISH assays

Renal cell carcinomas with MITF family abnormalities display diverse morphologies. In order to better understand the association between MITF alterations and clinicopathologic characteristics, this team performed FISH analysis on 85 renal tumors using our TFE3 and TFEB break apart probes.
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Alveolar soft-part sarcoma of the prostate: a case report and review of the literature

Alveolar soft-part sarcoma (ASPS) is a rare malignant soft tissue tumor. The subject of this study was a 21 year old man who presented with ASPS of the prostate. Our ASPL and TFE3 break apart probes were used to confirm fusion of the two genes in the patient’s tumor, helping to elucidate the underlying genetic drivers of this extremely rare, aggressive neoplasm.
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Gastric Perivascular Epithelioid Cell Tumor (PEComa): A Morphologic, Immunohistochemical, and Molecular Study Cell Tumor (PEComa)

Gastric Perivascular epithelioid cell tumor (PEComa) is an extremely rare tumor type - at the time of the study, only 7 cases had been reported so far. In this study, 2 new cases of PEComa were histologically and cytogenetically analyzed. In light of a recent study on a case of PEComa that harbored TFE3 fusion (and also exhibited unique features not typical of conventional PEComa), the tumors were screened for TFE3 rearrangements using Empire Genomics' TFE3 break-apart probe. Neither of the tumors were found to display TFE3 translocations.
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Clinicopathological Characterization of Renal Cell Carcinoma in Young Adults: a contemporary update and review of literature

Compared to adult renal cell carcinoma (RCC), pediatric and young adult RCC is fairly rare and poorly characterized. This team wanted to explore the genetic, molecular, and clinical spectrum of childhood and young adult RCC. They analyzed 68 RCC patients, all age 30 years or younger, using IHC and FISH. Our TFE3 and TFEB break apart FISH probes were used to detect rearrangements of the genes in cases that were morphologically suspicious for TFE3/TFEB translocations.
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