SFI1-LIMK2 Fusion FISH Probe
The SFI1-LIMK2 Fusion FISH Probe is used to confirm a fusion of the SFI1 and LIMK2 genes. The fusion of the SFI1 and LIMK2 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SFI1-LIMK2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-RERE | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-REOR | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-REGO | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-REGR | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-REAQ | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-ORRE | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-OROR | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-ORGO | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-GORE | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-GOOR | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-GOGO | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-GOGR | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-GRRE | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-GROR | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-GRGO | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-GRGR | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-AQRE | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-AQOR | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-AQGO | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-AQGR | 20 (40 μL) | 200 μL |
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| SFI1-LIMK2-20-AQAQ | 20 (40 μL) | 200 μL |
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LIMK2 Gene Summary
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: LIM Domain Kinase 2
Chromosome: CHR22: 31608249 -31676066
Locus: 22q12.2
SFI1 Gene Summary
The SFI1 Centrin Binding Protein (SFI1) gene is located on chr22 :31892260-32014534 at 22q12.2.
Gene Name: SFI1 Centrin Binding Protein
Chromosome: CHR22: 31892260 -32014534
Locus: 22q12.2
Gene Diseases
The SFI1 LIMK2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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