SF3B3-ADAM12 Fusion FISH Probe
The SF3B3-ADAM12 Fusion FISH Probe is used to confirm a fusion of the SF3B3 and ADAM12 genes. The fusion of the SF3B3 and ADAM12 genes has been associated with Testicular Germ Cell Tumors. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SF3B3-ADAM12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-RERE | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-REOR | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-REGO | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-REGR | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-REAQ | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-ORRE | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-OROR | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-ORGO | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-ORAQ | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-GORE | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-GOOR | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-GOGO | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-GOGR | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-GOAQ | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-GRRE | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-GROR | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-GRGO | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-GRGR | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-GRAQ | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-AQRE | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-AQOR | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-AQGO | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-AQGR | 20 (40 μL) | 200 μL |
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| SF3B3-ADAM12-20-AQAQ | 20 (40 μL) | 200 μL |
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ADAM12 Gene Summary
This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
Gene Name: ADAM Metallopeptidase Domain 12
Chromosome: CHR10: 127702901 -128077127
Locus: 10q26.2
SF3B3 Gene Summary
This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair. [provided by RefSeq, Jul 2008]
Gene Name: Splicing Factor 3b Subunit 3
Chromosome: CHR16: 70557690 -70611571
Locus: 16q22.1
Gene Diseases
The SF3B3 ADAM12 Fusion has been associated with the following diseases:
| Disease Name |
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| Testicular Germ Cell Tumors |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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