SF3A2-AZU1 Fusion FISH Probe
The SF3A2-AZU1 Fusion FISH Probe is used to confirm a fusion of the SF3A2 and AZU1 genes. The fusion of the SF3A2 and AZU1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SF3A2-AZU1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-RERE | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-REOR | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-REGO | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-REGR | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-REAQ | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-ORRE | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-OROR | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-ORGO | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-GORE | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-GOOR | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-GOGO | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-GOGR | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-GRRE | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-GROR | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-GRGO | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-GRGR | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-AQRE | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-AQOR | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-AQGO | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-AQGR | 20 (40 μL) | 200 μL |
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| SF3A2-AZU1-20-AQAQ | 20 (40 μL) | 200 μL |
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AZU1 Gene Summary
Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015]
Gene Name: Azurocidin 1
Chromosome: CHR19: 827830 -832017
Locus: 19p13.3
SF3A2 Gene Summary
This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein. [provided by RefSeq, Jul 2008]
Gene Name: Splicing Factor 3a Subunit 2
Chromosome: CHR19: 2236815 -2248678
Locus: 19p13.3
Gene Diseases
The SF3A2 AZU1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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