SF1-HRASLS2 Fusion FISH Probe
The SF1-HRASLS2 Fusion FISH Probe is used to confirm a fusion of the SF1 and HRASLS2 genes. The fusion of the SF1 and HRASLS2 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SF1-HRASLS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-RERE | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-REOR | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-REGO | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-REGR | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-REAQ | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-ORRE | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-OROR | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-ORGO | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-GORE | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-GOOR | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-GOGO | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-GOGR | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-GRRE | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-GROR | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-GRGO | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-GRGR | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-AQRE | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-AQOR | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-AQGO | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-AQGR | 20 (40 μL) | 200 μL |
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| SF1-HRASLS2-20-AQAQ | 20 (40 μL) | 200 μL |
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SF1 Gene Summary
This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Gene Name: Splicing Factor 1
Chromosome: CHR11: 64532075 -64546316
Locus: 11q13.1
HRASLS2 Gene Summary
The protein encoded by this gene has both phospholipase and acyltransferase activities and acts as a tumor suppressor. The encoded protein can hydrolyze dipalmitoylated phosphatidylcholine (PC) to palmitic acid and lyso-PC. In addition, this protein can catalyze the N-acylation of phosphatidylethanolamine and can catalyze the O-acylation of lyso-PC to form PC. [provided by RefSeq, Jul 2016]
Gene Name: HRAS Like Suppressor 2
Chromosome: CHR11: 63320241 -63330855
Locus: 11q12.3
Gene Diseases
The SF1 HRASLS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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