SF1-EHD1 Fusion FISH Probe
The SF1-EHD1 Fusion FISH Probe is used to confirm a fusion of the SF1 and EHD1 genes. The fusion of the SF1 and EHD1 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SF1-EHD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| SF1-EHD1-20-AQAQ | 20 (40 μL) | 200 μL |
|
SF1 Gene Summary
This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Gene Name: Splicing Factor 1
Chromosome: CHR11: 64532075 -64546316
Locus: 11q13.1
EHD1 Gene Summary
This gene belongs to a highly conserved gene family encoding EPS15 homology (EH) domain-containing proteins. The protein-binding EH domain was first noted in EPS15, a substrate for the epidermal growth factor receptor. The EH domain has been shown to be an important motif in proteins involved in protein-protein interactions and in intracellular sorting. The protein encoded by this gene is thought to play a role in the endocytosis of IGF1 receptors. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
Gene Name: EH Domain Containing 1
Chromosome: CHR11: 64620207 -64646191
Locus: 11q13.1
Gene Diseases
The SF1 EHD1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|