SETX-RAB14 Fusion FISH Probe
The SETX-RAB14 Fusion FISH Probe is used to confirm a fusion of the SETX and RAB14 genes. The fusion of the SETX and RAB14 genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SETX-RAB14-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-RERE | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-REOR | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-REGO | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-REGR | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-REAQ | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-ORRE | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-OROR | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-ORGO | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-ORAQ | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-GORE | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-GOOR | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-GOGO | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-GOGR | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-GOAQ | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-GRRE | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-GROR | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-GRGO | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-GRGR | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-GRAQ | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-AQRE | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-AQOR | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-AQGO | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-AQGR | 20 (40 μL) | 200 μL |
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| SETX-RAB14-20-AQAQ | 20 (40 μL) | 200 μL |
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SETX Gene Summary
This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4). [provided by RefSeq, Jul 2008]
Gene Name: Senataxin
Chromosome: CHR9: 135136826 -135230372
Locus: 9q34.13
RAB14 Gene Summary
RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]
Gene Name: RAB14, Member RAS Oncogene Family
Chromosome: CHR9: 123940414 -123964365
Locus: 9q33.2
Gene Diseases
The SETX RAB14 Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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