SETDB1-PKP4 Fusion FISH Probe
The SETDB1-PKP4 Fusion FISH Probe is used to confirm a fusion of the SETDB1 and PKP4 genes. The fusion of the SETDB1 and PKP4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SETDB1-PKP4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-RERE | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-REOR | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-REGO | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-REGR | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-OROR | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-GORE | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-GROR | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| SETDB1-PKP4-20-AQAQ | 20 (40 μL) | 200 μL |
|
PKP4 Gene Summary
Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]
Gene Name: Plakophilin 4
Chromosome: CHR2: 159313475 -159537940
Locus: 2q24.1
SETDB1 Gene Summary
This gene encodes a histone methyltransferase which regulates histone methylation, gene silencing, and transcriptional repression. This gene has been identified as a target for treatment in Huntington Disease, given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis. Alternatively spliced transcript variants of this gene have been described.[provided by RefSeq, Jun 2011]
Gene Name: SET Domain Bifurcated 1
Chromosome: CHR1: 150898814 -150937220
Locus: 1q21.3
Gene Diseases
The SETDB1 PKP4 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|