SETD5-MCM7 Fusion FISH Probe
The SETD5-MCM7 Fusion FISH Probe is used to confirm a fusion of the SETD5 and MCM7 genes. The fusion of the SETD5 and MCM7 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| SETD5-MCM7-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-RERE | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-REOR | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-REGO | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-REGR | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-OROR | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-GORE | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-GROR | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| SETD5-MCM7-20-AQAQ | 20 (40 μL) | 200 μL |
|
MCM7 Gene Summary
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Gene Name: Minichromosome Maintenance Complex Component 7
Chromosome: CHR7: 99690403 -99699427
Locus: 7q22.1
SETD5 Gene Summary
This function of this gene has yet to be determined but based on sequence similarity to other SET domain proteins it may function as a histone methyltransferase. Mutations in this gene have been associated with an autosomal dominant form of intellectual disability. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2017]
Gene Name: SET Domain Containing 5
Chromosome: CHR3: 9439402 -9519838
Locus: 3p25.3
Gene Diseases
The SETD5 MCM7 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|