SETBP1-ARNTL Fusion FISH Probe
The SETBP1-ARNTL Fusion FISH Probe is used to confirm a fusion of the SETBP1 and ARNTL genes. The fusion of the SETBP1 and ARNTL genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SETBP1-ARNTL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-RERE | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-REOR | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-REGO | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-REGR | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-REAQ | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-ORRE | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-OROR | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-ORGO | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-ORAQ | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-GORE | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-GOOR | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-GOGO | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-GOGR | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-GOAQ | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-GRRE | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-GROR | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-GRGO | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-GRGR | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-GRAQ | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-AQRE | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-AQOR | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-AQGO | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-AQGR | 20 (40 μL) | 200 μL |
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| SETBP1-ARNTL-20-AQAQ | 20 (40 μL) | 200 μL |
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ARNTL Gene Summary
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Gene Name: Aryl Hydrocarbon Receptor Nuclear Translocator Like
Chromosome: CHR11: 13299324 -13408812
Locus: 11p15.3
SETBP1 Gene Summary
This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Gene Name: SET Binding Protein 1
Chromosome: CHR18: 42260862 -42648475
Locus: 18q12.3
Gene Diseases
The SETBP1 ARNTL Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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