SESN1-METTL1 Fusion FISH Probe
The SESN1-METTL1 Fusion FISH Probe is used to confirm a fusion of the SESN1 and METTL1 genes. The fusion of the SESN1 and METTL1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| SESN1-METTL1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-RERE | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-REOR | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-REGO | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-REGR | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-REAQ | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-ORRE | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-OROR | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-ORGO | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-ORAQ | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-GORE | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-GOOR | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-GOGO | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-GOGR | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-GOAQ | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-GRRE | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-GROR | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-GRGO | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-GRGR | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-GRAQ | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-AQRE | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-AQOR | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-AQGO | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-AQGR | 20 (40 μL) | 200 μL |
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| SESN1-METTL1-20-AQAQ | 20 (40 μL) | 200 μL |
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METTL1 Gene Summary
This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]
Gene Name: Methyltransferase Like 1
Chromosome: CHR12: 58162350 -58165914
Locus: 12q14.1
SESN1 Gene Summary
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Name: Sestrin 1
Chromosome: CHR6: 109307639 -109415708
Locus: 6q21
Gene Diseases
The SESN1 METTL1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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